Key result
The presence of a conotruncal anomaly in fetuses with heterotaxy syndrome was an independent risk factor for mortality (HR 5.09; 95% CI 1.09-23.71; p=0.039).
Why the study?
The study aimed to define cardiac and extracardiac malformations in fetuses with heterotaxy syndrome and to determine perinatal and childhood prognosis.
Population
62 fetuses diagnosed with heterotaxy syndrome on antenatal ultrasonography
Comparison
Right atrial isomerism vs left atrial isomerism
Design
Retrospective study
Authors
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In fetuses with heterotaxy syndrome, the presence of conotruncal anomalies, hydrops fetalis, and univentricular physiology are associated with poor outcomes and increased mortality.
Cohort (n=62)
No
Hazard Ratio: 5.09 (95% CI 1.09–23.71)
p-value: p=0.039
In fetuses with heterotaxy syndrome, the presence of conotruncal anomalies, hydrops fetalis, and univentricular physiology are associated with poor outcomes and increased mortality.
Akalın et al. (2022) conducted a cohort in Heterotaxy syndrome (n=62). Conotruncal anomaly vs. Absence of conotruncal anomaly was evaluated on Mortality (HR 5.09, 95% CI 1.09-23.71, p=0.039). The presence of a conotruncal anomaly in fetuses with heterotaxy syndrome was an independent risk factor for mortality (HR 5.09; 95% CI 1.09-23.71; p=0.039).
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