All articles of this category The directed ortho lithiation of 2- tert -butoxycarbonylamino-3-methylpyridine (6a) has provided a convenient method for the preparation of 1 H -pyrrolo[2,3- b ]pyridine ( 4a , 7-azaindole). This procedure has been used to prepare a range of 3-substituted 2- tert -butoxycarbonylaminopyridines 6 , 2- and 3-substituted and 2,3-disubstituted 1 H -pyrrolo[2,3- b ]pyridines 4 and shown to be of value in the preparation of 1 H -pyrrolo[3,2- c ]pyridine ( 15 , 5-azaindole) and 1 H -pyrrolo[2,3- c ]pyridine ( 18 , 6-azaindole) and derivatives. directed ortho metallation - 3-substituted-2-aminopyridines - 5,- 6- and 7-azaindoles
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Hands et al. (1996) studied this question.