Key result
Propolis treatment at 30 mg/kg or 60 mg/kg significantly reduced serum levels of total cholesterol, triglycerides, and LDL, and increased HDL in mice with Triton-WR1339-induced hyperlipidemia (P<0.05).
Why the study?
Does propolis improve lipid profiles and regulate lipid metabolism proteins in mice with acute hyperlipidemia?
Does propolis improve lipid profiles and regulate lipid metabolism proteins in mice with acute hyperlipidemia?
Propolis exhibits lipid-lowering effects in a mouse model of acute hyperlipidemia by regulating hepatic lipid transport proteins.
Hypothesis-generating for propolis in hyperlipidemia; leaves open clinical translation pending human trials.
OBJECTIVE: To evaluate the therapeutic effect of propolis against Triton-WR1339-induced hyperlipidemia in mice and explore the underlying mechanism. METHODS: =10), including the control group, hyperlipidemia model group, fenofibrate (30 mg/kg) treatment group, and 4 treatment groups treated with low- (30 mg/kg) or high-dose (60 mg/kg) propolis HB01 or HB02. In all but the control group, acute hyperlipidemia models were established by intramuscular injection of Triton WR-1339, and corresponding treatments were administered via gastric lavage for 7 days. After the treatments, blood samples were collected for testing the levels of total cholesterol (TC), triglycerides (TG), highdensity lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), malondialdehyde (MDA), superoxide dismutase (SOD), alanine aminotransferase (GPT), and aspartate aminotransferase (GOT); Western blotting was used to detect the expressions of the proteins involved in lipid metabolism in the liver tissues including ABCA1, ABCG8, LDLR, and SR-B1. RESULTS: < 0.05), especially by the latter. CONCLUSIONS: The lipid-lowering effects of propolis are mediated by improving lipid metabolism and regulating the expressions of lipid transport proteins in the liver tissue.
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Huang et al. (2018) studied Triton-WR1339-induced hyperlipidemia (n=70). Propolis vs. Triton WR-1339 model group was evaluated on Blood lipid levels (TC, TG, LDL, HDL) (p=<0.05). Propolis treatment at 30 mg/kg or 60 mg/kg significantly reduced serum levels of total cholesterol, triglycerides, and LDL, and increased HDL in mice with Triton-WR1339-induced hyperlipidemia (P<0.05).
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