Key result
In older adults with severe aortic stenosis, elevated IL-6 was a significant independent predictor of frailty (OR 1.037; 95% CI 1.001-1.074; p=0.043).
Why the study?
Frailty and severe aortic stenosis share pathophysiological mechanisms including chronic inflammation and calcium metabolism dysregulation, which may influence their development and progression.
Observational (n=191)
Odds Ratio: 1.037 (95% CI 1.001–1.074)
p-value: p=0.043
In older adults with severe aortic stenosis, elevated IL-6 levels are independently associated with frailty, suggesting systemic inflammation may play a role in the functional decline of this population.
IL-6 was independently associated with frailty; leaves open whether biomarker testing refines assessment beyond SPPB in severe AoS.
Background: Frailty and severe aortic stenosis (AoS) are critical conditions in older adults, both of which share pathophysiological mechanisms including chronic inflammation and calcium metabolism dysregulation, potentially influencing the development and progression of these conditions. This study aimed to analyze systemic inflammation and calcium homeostasis biomarkers and their associations with frailty in older adults with severe AoS. Methods: This prospective study included 191 patients aged ≥75 years with severe AoS who were candidates for aortic valve replacement and were evaluated at a Geriatrics Frailty Assessment and Intervention Clinic. Frailty was defined as a score ≤6 on the Short Physical Performance Battery (SPPB). Biomarkers analyzed included aortic valve calcium score, parathyroid hormone (PTH), calcidiol (vitamin D), calcium, phosphate, creatinine, interleukin-6 (IL-6), and the Systemic Immune-Inflammation Index. Multivariate logistic regression was performed to identify independent predictors of frailty. Results: Of the 191 patients studied, 53.9% were women, with a mean age of 84.1 ± 4.1 years. Frailty was identified in 28.3% of patients (mean SPPB score 7.6 ± 2.5). Statistically significant differences between frail and non-frail patients were observed for PTH (87.7 ± 61.1 pg/mL vs. 70 ± 44.4 pg/mL, p = 0.028) and IL-6 (10.4 ± 11.2 pg/mL vs. 7 ± 8.2 pg/mL, p = 0.049). Notably, in the multivariate model, IL-6 emerged as a significant independent predictor of frailty (OR 1.037; CI 1.001–1.074, p = 0.043). Conclusions: IL-6 was identified as a biomarker significantly associated with frailty in older adults with severe AoS. Evaluating IL-6 could enhance the precision of frailty assessments, complement functional measures, and support clinical decision-making in this population.
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Suárez et al. (2025) conducted an observational in Severe aortic stenosis and frailty (n=191). Interleukin-6 (IL-6) was evaluated on Frailty (defined as Short Physical Performance Battery score ≤6) (OR 1.037, 95% CI 1.001-1.074, p=0.043). In older adults with severe aortic stenosis, elevated IL-6 was a significant independent predictor of frailty (OR 1.037; 95% CI 1.001-1.074; p=0.043).
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