The morphinan skeleton was effectively synthesized by an intramolecular Mannich-type reaction.Further transformation led to the total synthesis of morphine.2) Pd(OAc) 2 MeCN rt, 92% (2 steps) MeO O H NCO 2 Me O MeO O H NCO 2 Me O 24 aq H 2 O 2 NaOH MeCN 0 °C to rt 91% MeO O H NCO 2 Me O 25 O H 2 NNH 2 •H 2 O AcOH MeOH reflux
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Fukuyama et al. (2009) studied this question.
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