Reaction of alcohols with tert-butyldimethylsilyl chloride in DMSO–hexane provides the corresponding tert-butyldimethylsilyl ethers in high yields under mild reaction conditions. This convenient reaction proceeds very smoothly at room temperature without a catalyst. Additionally, alcohols having an allylic alcohol, cyclopropane, and tetrahydrofuran moiety underwent chemoselective silylation to give the TBS ethers in good yields with no undesired reactions.
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Watahiki et al. (2003) studied this question.
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