Key result
Enterovirus D68 was detected in 7.4% of patients with influenza-like illness or acute flaccid paralysis in Senegal in 2016, with all strains belonging to the newly defined subclade B3.
Why the study?
Despite global outbreaks, EV-D68 circulation remained largely unexplored in Africa following low levels noted during the 2014 outbreak in Senegal.
Cross-Sectional (n=596)
Yes
This study provides the first evidence of EV-D68 B3 subclade circulation in Africa from patients with ILI and AFP during a 2016 outbreak in Senegal.
EV-D68 B3 circulation in Senegal supports regional surveillance inclusion; extends geographic data but leaves open clinical impact.
Following the 2014 outbreak, active surveillance of the EV-D68 has been implemented in many countries worldwide. Despite subsequent EV-D68 outbreaks (2014 and 2016) reported in many areas, EV-D68 circulation remains largely unexplored in Africa except in Senegal, where low levels of EV-D68 circulation were first noted during the 2014 outbreak. Here we investigate subsequent epidemiology of EV-D68 in Senegal from June to September 2016 by screening respiratory specimens from ILI and stool from AFP surveillance. EV-D68 was detected in 7.4% (44/596) of patients; 40 with ILI and 4 with AFP. EV-D68 detection was significantly more common in children under 5 years (56.8%, p = 0.016). All EV-D68 strains detected belonged to the newly defined subclade B3. This study provides the first evidence of EV-D68 B3 subclade circulation in Africa from patients with ILI and AFP during a 2016 outbreak in Senegal. Enhanced surveillance of EV-D68 is needed to better understand the epidemiology of EV-D68 in Africa.
No takes yet. Share an insight, caveat, or question.
Fall et al. (2019) conducted a cross-sectional in Influenza-like illness (ILI) and Acute Flaccid Paralysis (AFP) (n=596). Enterovirus D68 (EV-D68) infection vs. EV-D68 negative patients was evaluated on EV-D68 detection rate. Enterovirus D68 was detected in 7.4% of patients with influenza-like illness or acute flaccid paralysis in Senegal in 2016, with all strains belonging to the newly defined subclade B3.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: