The synthetic potential of arynes can be exploited through a new method for their generation from functionalized aryl magnesium reagents and controlled reaction. Arynes with functional groups such as ester, nitrile, ketone, or nitro groups, or with a quinolyl skeleton, can be formed from polyfunctionalized 2-iodo aryl 4-chlorobenezenesulfonates and trapped in 68–93 % yield with furan (see scheme).
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Sapountzis et al. (2004) studied this question.
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