A visible-light-induced remote oxyfluoroalkylation, including ketofluoroalkylation and hydroxytrifluoromethylation, of heteroalkynes is developed with dimethyl sulfoxide (DMSO) and H 2 O as the oxygen source, respectively. It provides a facile access to complex fluoroalkylated ( Z )-alkenes in satisfactory yields with excellent regio-, stereo-, and site-selectivity. The reaction involves an uncommon vinyl radical-induced intermolecular C(sp 3 )–H functionalization, thus offering a good platform for the development of remote difunctionalization of alkynes.
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Shang et al. (2020) studied this question.
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