Methamphetamine use and psychotic symptoms: findings from a New Zealand longitudinal birth cohort

Joseph M. Boden; James Foulds; Giles Newton‐Howes; Rebecca McKetin

doi:10.1017/s0033291721002415

June 17, 2021Psychological Medicine

Methamphetamine use and psychotic symptoms: findings from a New Zealand longitudinal birth cohort

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Key Points

To determine the longitudinal relationship between methamphetamine use and psychotic symptoms and examine whether past use creates enduring vulnerability to psychosis.
Followed a longitudinal birth cohort (N = 1265 at birth) assessed at ages 18, 21, 25, 30, and 35.
Used generalized estimating equations to model the association of methamphetamine use with psychotic symptom presence and symptom count.
Adjusted for childhood characteristics, family socioeconomic background, family functioning, and concurrent cannabis use.
Methamphetamine use was associated with an elevated overall risk of any psychotic symptom (adjusted OR 1.33, 95% CI 1.03–1.72) and higher symptom counts (IRR 1.24, 95% CI 1.02–1.50).
The elevated psychosis risk was concentrated among individuals reporting at least weekly use (adjusted OR 2.85, 95% CI 1.21–6.69), whereas less-than-weekly use showed no significant association.
No evidence emerged of persistent vulnerability to psychotic symptoms between ages 30 and 35 in participants without ongoing methamphetamine use.

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Longitudinal cohort study reveals increased risk of psychotic symptoms following frequent methamphetamine use in young adults, indicating that psychosis risk is concentrated among regular, recent...

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Boden et al. (2021) studied this question.

synapsesocial.com/papers/6a94cb21aa92d0f3572c88c1 https://doi.org/10.1017/s0033291721002415

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Methamphetamine use and psychotic symptoms: findings from a New Zealand longitudinal birth cohort

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Methamphetamine use and psychotic symptoms: findings from a New Zealand longitudinal birth cohort

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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