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January 1, 1991The Journal of AntibioticsOpen Access

Cyclothiazomycin, a novel polythiazole-containing peptide with renin inhibitory activity. Taxonomy, fermentation, isolation and physico-chemical characterization.

Masahiro Aoki Tatsuo Ohtsuka Masayoshi Yamada YOSHIKO OHBA HLROYUKI YOSHIZAKI HLDEYUKI YASUNO Takashi Sano Junko Watanabe Kazuteru Yokose Haruo Seto

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Abstract

Cyclothiazomycin is a novel renin inhibitor produced by Streptomyces sp. NR0516. It was isolated from fermentation broth by extraction with butyl alcohol, QAE-Toyopearl column chromatography and preparative HPLC. Cyclothiazomycin, which was determined to be a unique polythiazole-containing bicyclic peptide, exhibited inhibitory activity against human plasma renin with IC50 being 1.7 microM.

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Aoki et al. (1991) studied this question.

synapsesocial.com/papers/6a94cb38d44cea3cdd827578 https://doi.org/10.7164/antibiotics.44.582

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