Experimental study demonstrates efficient ICl-induced cyclization of alkynones into 3-iodochromones, highlighting versatile access to complex heterocyclic scaffolds.
Key Points
Develop an efficient, mild synthetic method to construct 3-iodochromones and related heteroatom derivatives using iodine monochloride-promoted cyclization.
Subjected heteroatom-substituted alkynones to iodine monochloride (ICl)-mediated cyclization under mild reaction conditions.
Coupled the resulting iodinated heterocycles to secondary palladium-catalyzed reactions to introduce molecular complexity across varied scaffold types.
ICl-induced cyclization tolerated diverse functional groups and consistently delivered target chromones in good to excellent yields.
The cyclization framework effectively generalized to iodothiochromenones and iodoquinolinones, enabling rapid diversification into complex furans and polycyclic systems.