A new chiral o-hydroxyaryldiazaphosphonodiamide 1 was synthesized from (−)-α-methylbenzylamine, it was found to be efficient ligand for the Ti(O-iPr)4 catalyzed asymmetric trimethylsilylcyanation of aldehydes. Corresponding aromatic cyanohydrins were obtained in good chemical yield and enantiomeric excesses (e.e.s) up to 90%.
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Yang et al. (2002) studied this question.
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