Evidence is presented to show that solutions of purified thrombin contain a substance which reacts slowly with prothrombin, causing inactivation of the latter. The destructive agent is not present in the calcium, prothrombin, or thromboplastin solutions from which the thrombin is produced. The factor is heat-labile and the evidence indicates that thrombin itself is the factor in question.
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Mertz et al. (1939) studied this question.