Congenital adrenal hypoplasia--an X-linked disease.

Dacou and DiGeorge (1968) reported in abstract form their findings from a study of three male infants with adrenal hypoplasia. These infants by history had a common mother and two different fathers. At about the same time Bickham, Silvestre, and Mellinger (1968) reported on two affected male sibs who had a common mother and different fathers. Both authors suggested X-linked inheritance in this disorder, but genetic data documenting the pater- nity of these individuals were not presented in either instance.