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June 1, 1972Biochemical JournalOpen Access

Kinetics of the reversible reaction of papain with 5,5′-dithiobis-(2-nitrobenzoate) dianion: evidence for nucleophilic reactivity in the un-ionized thiol group of cysteine-25 and for general acid catalysis by histidine-159 of the reaction of the 5-mercapto-2-nitrobenzoate dianion with the papain-5-mercapto-2-nitrobenzoate mixed disulphide

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Authors

GLG. LittleSt Bartholomew's HospitalKBK BrocklehurstUniversity of East Anglia

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Little et al. (1972) studied this question.

synapsesocial.com/papers/6a94d0855f3b0bfa3be60e9dhttps://doi.org/10.1042/bj1280475
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The effect of pH on the affinities of enzymes for substrates and inhibitors1953 · 483 citations
  2. 2Reactivities of the various protonic states in the reactions of papain and of L-cysteine with 2,2′- and with 4,4′- dipyridyl disulphide: evidence for nucleophilic reactivity in the un-ionized thiol group of the cysteine-25 residue of papain occasioned by its interaction with the histidine-159-asparagine-175 hydrogen-bonded system1972 · 71 citations
  3. 3IV. Cysteine proteinases1970 · 49 citations