In most biological syntheses each step is controlled by a different gene. conclusion was suggested by such combined genetic and biochemical as those on the anthocyanin pigments from which it appeared that particular gene regulates the oxidation (or methylation, or the nature the glucosides) at particular carbon atoms of the anthocyanin molecules. of the eye pigments of Drosophila and the hair pigments guinea pigs each indicate that the different steps in a particular synthesis controlled by different genes. Almost overwhelming support for the is coming from studies of "biochemical" mutations in Neurospora.
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Sterling Emerson (1944) studied this question.
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