Key result
Among 12 patients with hypertriglyceridaemia-induced acute pancreatitis, all were managed with conservative therapy, restricted fat diet, and anti-lipid therapy, with a median hospital stay of 5.5 days.
Why the study?
Hypertriglyceridaemia is a rare cause of acute pancreatitis, accounting for less than 5% of cases, prompting a review of clinical presentation, demographics, and management.
Observational (n=12)
No
Hypertriglyceridaemia is a rare cause of acute pancreatitis (2.8% of cases) that can be successfully managed with conservative therapy, dietary restriction, and long-term anti-lipid therapy.
Supports conservative management of hypertriglyceridaemia pancreatitis; leaves open optimal recurrence prevention strategies.
BACKGROUND: Pancreatitis secondary to hypertriglyceridaemia is rare, accounting for less than 5% of pancreatitis presentations. We reviewed our institutional experience with triglyceridaemia induced acute pancreatitis to report the clinical presentation, patient demographics and clinical management. METHODS: The Acute Surgical Unit database at a high-volume general surgical referral centre was queried to identify cases of acute pancreatitis secondary to hypertriglyceridaemia between 2016 and 2019. Patient demographics, clinical manifestations, biochemical derangements and treatment regimens were analysed. Current related literature was reviewed. RESULTS: There were 496 presentations for acute pancreatitis of which 14 presentations (2.8%), amongst 12 patients were due to hypertriglyceridaemia. The mean triglyceride level at presentation was 92.46 (standard deviation 46.9) mmol/L. Ten patients (83%) had poorly controlled type 2 diabetes. All patients were managed using conservative therapy combined with a restricted fat diet and commenced on long-term anti-lipid therapy to manage associated risk factors. In addition, 10 patients received an insulin infusion and one patient received insulin infusion, plasmapheresis and heparin infusion in combination. The median length of hospital stay was 5.5 (range 3-13) days. Two patients (16%) developed a recurrent episode related to non-compliance to medical therapy. CONCLUSION: Hypertriglyceridaemia is a rare cause of acute pancreatitis. Successful management involves the treatment of acute pancreatitis in conjunction with long-term anti-lipid therapy and optimisation of associated risk factors.
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Tabone et al. (2020) conducted an observational in Acute pancreatitis secondary to hypertriglyceridaemia (n=12). Conservative therapy, restricted fat diet, and anti-lipid therapy was evaluated on Clinical presentation, patient demographics, and clinical management. Among 12 patients with hypertriglyceridaemia-induced acute pancreatitis, all were managed with conservative therapy, restricted fat diet, and anti-lipid therapy, with a median hospital stay of 5.5 days.
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