Practical Optical Resolution of Planar Chiral Pseudo-ortho-disubstituted [2.2]Paracyclophane

We describe the practical optical resolution of rac-pseudo-ortho-dibromo[2.2]paracyclophane to obtain the parent compound for a variety of cyclophane-based planar chiral compounds such as enantiopure chiral ligand [2.2]PHANEPHOS. In addition, the obtained enantiopure planar chiral (R)- and (S)-pseudo-ortho-disubstituted [2.2]paracyclophanes can be used as the building blocks for optically active carbon-rich compounds.