THE ROLE of the pituitary adrenotrophic hormone in the regulation of the lymphocytes and other cellular elements of the blood has been elucidated by examination of the blood picture of animals following single injections of the hormone (Dougherty and White, 1944). The action of the pituitary hormone is due to the trophic influence it exerts on the adrenal cortex. The striking alterations in blood picture seen following single injections of hormone led to examination of the effects of continued treatment with pituitary adrenotrophic factor. These results have been compared with blood changes in adrenalectomized animals. Mice of both sexes 60 to 80 days of age and of the CBA strain (Strong) were used. The data were similar in both sexes. Male rats (Sprague-Dawley strain) weighing approximately 200 gms at the time of adrenalectomy were used. All animals were kept at a constant environmental temperature. Purina Fox Chow and water were available at all times.
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White et al. (1945) studied this question.