Lipedema of the Legs: A Syndrome Characterized by Fat Legs and Edema

Article1 May 1951LIPEDEMA OF THE LEGS: A SYNDROME CHARACTERIZED BY FAT LEGS AND EDEMALESTER E. WOLD, M.D., EDGAR A. HINES JR., M.D., F.A.C.P., EDGAR V. ALLEN, M.D., F.A.C.P.LESTER E. WOLD, M.D.Search for more papers by this author, EDGAR A. HINES JR., M.D., F.A.C.P.Search for more papers by this author, EDGAR V. ALLEN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-5-1243 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere is little in the literature on abnormal localized depositions of body fat to clarify the syndrome of lipedema of the legs which two of us (E. V. A. and E. A. H.) described in 1940.1Confusion and uncertainty, both manifested in an extensive article by Lyon2in 1910, are demonstrated by the use of such terms as "oedeme hystérique" and "pseudo-edema." We are not concerned in this presentation with the type of lipodystrophy (lipodystrophia progressiva) which is generally felt to be characterized by loss of subcutaneous fat of the upper half of the body and increased deposition of fat...Bibliography1. AllenHines EVEA: Lipedema of the legs: a syndrome characterized by fat legs and orthostatic edema, Proc. Staff Meet., Mayo Clin. 15: 184-187, 1940. Google Scholar2. Lyon IP: Adiposis and lipomatosis; considered in reference to their constitutional relations and symptomatology, Arch. Int. Med. 6: 28-120, 1910. CrossrefGoogle Scholar3. ReubenZamkinFox MSHOHR: Lipodystrophia progressiva, Arch. Pediat. 41: 480-488, 1924. Google Scholar4. Wilder J: Bemerkungen zur Frage der Lipodystrophia progressiva. (Zugleich Mitteilung eines Falles mit Hypertrophie eines Beines), Ztschr. f. d. ges. Neurol. u. Psychiat. 116: 275-289, 1928. CrossrefGoogle Scholar5. Wilkinson GR: Progressive lipodystrophy—a case report and discussion of the problem, South. Med. and Surg. 103: 315-317, 1941. Google Scholar6. Whittle CH: Lipodystrophia progressiva, Proc. Roy. Soc. Med. 73: 153, 1944. Google Scholar7. PlossBartelsBartels HHMP: Woman: an historical, gynecological and anthropological compendium, 1935, William Heinemann, Ltd., London, vol. 1, p. 300. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Received for publication June 7, 1949.From the Mayo Foundation and the Division of Medicine of the Mayo Clinic, Rochester, Minnesota. 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