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The protection of health and the prevention of infections depend on the efficiency of a strong immune system. Current research highlights the significant role of food-derived constituents, particularly polyphenols and beta-glucans, in modulating immunity. Beta-glucans, found in cereals, yeast, and fungi, boost both adaptive and innate immune responses via receptor-mediated mechanisms. This shows that these compounds have anti-infective action and can be applied as immunomodulatory medications. Polyphenols, established abundantly in tea, vegetables, and fruits, have effective antioxidant, anti-inflammatory, and microbiota-modulating properties that help to sustain immune system’s homeostasis. Their clinical confirmation of immunomodulatory mechanisms is described in this review. Moreover, it examines how bioactive compounds interact with vitamins and has prospective therapeutic prospects in combating infection, chronic inflammation, and aging. Bioavailability, novel delivery systems, and variation between persons are also comprised in the study. Additional research is required in personalized nutrition plans because of the important role bioactive foods have to play to promote immunity and health.
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Ahmed et al. (2026) studied this question.
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