What question did this study set out to answer?

To assess the effects of partial neuromuscular blockade on pharyngeal function, airway protection, and the coordination of breathing and swallowing in adults over 65 years of age.

October 25, 2013AnesthesiologyOpen Access

Pharyngeal Function and Breathing Pattern during Partial Neuromuscular Block in the Elderly

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Authors

ACAnna I. Hårdemark CedborgRemington College ESEva SundmanKarolinska University Hospital KBKatarina BodénKarolinska University Hospital

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Implication

Experimental study demonstrates increased pharyngeal dysfunction during partial neuromuscular block in older adults, indicating impaired airway protection before full recovery.

Key Points

To assess the effects of partial neuromuscular blockade on pharyngeal function, airway protection, and the coordination of breathing and swallowing in adults over 65 years of age.
Interventional study in 17 healthy elderly volunteers (mean age 73.5 yr) evaluated using manometry and videoradiography.
Rocuronium was administered to achieve steady-state train-of-four (TOF) ratios of 0.70 and 0.80, followed by monitoring of spontaneous recovery to a TOF ratio greater than 0.90.
Pharyngeal dysfunction increased from 37% at baseline control to 67% at a TOF ratio of 0.70 and 71% at a TOF ratio of 0.80, returning to baseline levels after recovery to TOF greater than 0.90.
Resting pressure in the upper esophageal sphincter decreased across all levels of partial neuromuscular block compared with baseline.
No measurable impairment in the coordination between breathing and swallowing was detected during partial block.

Cite This Study

Cedborg et al. (2013) studied this question.

synapsesocial.com/papers/6a94d51fa9fda6dc960f2abe https://doi.org/10.1097/aln.0000000000000043

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Implication

Experimental study demonstrates increased pharyngeal dysfunction during partial neuromuscular block in older adults, indicating impaired airway protection before full recovery.

Pharyngeal Function and Breathing Pattern during Partial Neuromuscular Block in the Elderly

Discussion

Member takes

Implication

Key Points

Cite This Study

Pharyngeal Function and Breathing Pattern during Partial Neuromuscular Block in the Elderly

Discussion

Member takes

Implication

Key Points

Cite This Study

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