Key result
Diabetes induced abnormal changes in cardiac structure and function and myocardial inflammatory responses in rats, associated with the activation of NLRP1/ASC/caspase 1 inflammasomes (P<0.01).
Why the study?
The study was conducted to observe myocardial NLRP1 inflammasome expression in rats on a high-fat and high-sugar diet and diabetic rats, analyzing its role in diabetic cardiomyopathy pathogenesis.
Does diabetes induce myocardial inflammatory response and cardiac dysfunction via NLRP1/ASC/caspase 1 inflammasome activation in a rat model?
Does diabetes induce myocardial inflammatory response and cardiac dysfunction via NLRP1/ASC/caspase 1 inflammasome activation in a rat model?
Diabetes induces abnormal cardiac structure and function and myocardial inflammation in rats, potentially mediated by the activation of the NLRP1/ASC/caspase 1 inflammasome pathway.
Supports NLRP1 inflammasome activation in diabetic rat cardiomyopathy; hypothesis-generating and leaves open human translation or therapeutic targeting.
OBJECTIVE: To observe the expression of NLRP1 inflammasomes in myocardial tissues in rats with a high-fat and highsugar diet and in diabetic rats analyze the role of NLRP1 inflammasomes in the pathogenesis of diabetic cardiomyopathy. METHODS: Male SD rats were divided into normal control group, high-sugar and high-fat diet (HC) group and diabetes group. Rat models of diabetes were established by intraperitoneal injection of streptozotocin (STZ; 30 mg/kg). Serum levels of cholesterol (TC), triglyceride (TG), and fasting insulin (FINS) were measured after 8 weeks of feeding, and the insulin resistance index (IRI) and insulin sensitivity index (ISI) were calculated; Echocardiographic evaluation of cardiac structure and function was performed, and Western blotting and real-time fluorescent quantitative PCR (RT-qRCP) were used to detect the protein and mRNA expressions of NLRP1, ASC, and caspase 1 in the myocardial tissue. CONCLUSIONS: Diabetes can cause abnormal changes in cardiac structure and functions and induce inflammatory response in the myocardium, which may be related to the activation of NLRP1/ASC/ caspase 1 inflammasomes.
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Li et al. (2020) studied Diabetic cardiomyopathy (n=30). High-sugar and high-fat diet plus streptozotocin vs. Normal control and high-sugar/high-fat diet alone was evaluated on Expression of NLRP1 inflammasomes and cardiac function (p=<0.01). Diabetes induced abnormal changes in cardiac structure and function and myocardial inflammatory responses in rats, associated with the activation of NLRP1/ASC/caspase 1 inflammasomes (P<0.01).
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