Key result
Autochthonous Trypanosoma cruzi infection in the Brazilian Amazon resulted in serious cardiac involvement, with 3 out of 4 reported cases dying despite benznidazol treatment.
Case Report (n=4)
Highlights the emergence of acute Chagas disease with severe cardiac involvement and high mortality in the Brazilian Amazon, revealing previously unknown pathogenicity of local T. cruzi strains.
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Raises caution for severe cardiac Chagas in Amazon; leaves open local strain virulence and treatment efficacy.
Four cases of serious cardiac attacks by autochthonous Trypanosoma cruzi infection from the Brazilian Amazon are reported; three of them occurred in micro-epidemic episodes. The manifestations included sudden fever, myalgia, dyspnea and signs of heart failure. Diagnosis was confirmed by specific exams, especially QBC (Quantitative Buffy Coat) and natural xenodiagnosis. Despite treatment with benznidazol, three patients died with serious myocarditis, renal failure and cardiac tamponade. The authors call attention to the emergence of this disease and reveal a previously unknown pathogenicity of T. cruzi strains in this area, added to a non-usual transmission form.
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Pinto et al. (2004) conducted a case report in Acute Chagas Disease (n=4). Trypanosoma cruzi infection was evaluated on Mortality. Autochthonous Trypanosoma cruzi infection in the Brazilian Amazon resulted in serious cardiac involvement, with 3 out of 4 reported cases dying despite benznidazol treatment.
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