Key result
Various drugs, including antioxidants, estrogens, vitamin A, ACE inhibitors, ARBs, and some hypolipemic, hypoglycemic, and beta-blocking agents, decrease plasma ADMA levels.
Why the study?
How do various pharmacological agents affect plasma asymmetric dimethylarginine (ADMA) levels?
How do various pharmacological agents affect plasma asymmetric dimethylarginine (ADMA) levels?
Answers are grounded in this paper and cite their sources.
Various cardiovascular and metabolic drugs can modulate plasma ADMA levels, which may indirectly improve endothelial function by reducing the inhibition of nitric oxide synthesis.
Asymmetric dimethylarginine (ADMA) is an endogenous methylated amino acid derived from arginine which can inhibit the activity of nitric oxide synthases. In various pathological states such as hypercholesterolemia, hyperglycemia, hyperhomocysteinemia, hypertension, coronary artery disease, heart failure, and stroke, plasma levels of ADMA may be increased and lead to inhibition of NO synthesis and endothelial dysfunction. Inhibition of ADMA synthesis or intensification of metabolism of this compound might indirectly lower ADMA. Antioxidants, estrogen, vitamin A, angiotensin converting enzyme inhibitors, angiotensin AT1 receptor antagonists, and also some hypolipemic, hypoglycemic and beta-adrenoreceptor blocking drugs decrease ADMA levels. In some situations like neurological disorders, decreased plasma levels of ADMA are noticed and drugs increasing the concentration of this compound could exert protective effects. It is reasonable to explore which drugs can increase or decrease ADMA levels and what their mechanism of that action is.
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Trocha et al. (2010) conducted a review in Elevated ADMA levels and endothelial dysfunction. Selected drugs (antioxidants, ACE inhibitors, ARBs, estrogens, hypolipemic, hypoglycemic, and beta-blocking drugs) was evaluated on Plasma asymmetric dimethylarginine (ADMA) levels. Various drugs, including antioxidants, estrogens, vitamin A, ACE inhibitors, ARBs, and some hypolipemic, hypoglycemic, and beta-blocking agents, decrease plasma ADMA levels.
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