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December 1, 1970Scandinavian Journal of Infectious Diseases

Severe Illness in Children Exposed to Natural Measles after Prior Vaccination against the Disease: A Report of Six Cases

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Why the study?

Does prior vaccination with inactivated measles vaccine cause severe illness upon exposure to natural measles in children?

Population

6 children previously vaccinated against measles who were exposed to natural measles

Design

Case_series

Authors

FBF. BuserUniversity of BernBMB MontagnonInstitut Mérieux (France)

Discussion

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Implication

Alerts clinicians to potential inactivated measles vaccine risks; hypothesis-generating for Arthus-type reactions in vaccine safety research.

Structured PICO

Does prior vaccination with inactivated measles vaccine cause severe illness upon exposure to natural measles in children?

P
Population
6 children previously vaccinated against measles who were exposed to natural measles
I
Intervention
Prior vaccination against measles (inactivated measles vaccine)
O
Outcome
Moderate to severe illnesssafety

Prior vaccination with inactivated measles vaccine may lead to severe Arthus-type reactions upon subsequent exposure to natural measles.

Cite This Study

Buser et al. (1970) studied this question.

synapsesocial.com/papers/6a94d8d41f4bf9b67c9e54dahttps://doi.org/10.3109/inf.1970.2.issue-3.01
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hemagglutination by Measles Virus. 4. A Simple Procedure for Production of High Potency Antigen for Hemagglutination-Inhibition (HI) Tests1962 · 216 citations
  2. 2Side Reaction to Measles Vaccination Suggesting the Arthus Phenomenon1967 · 74 citations
  3. 3Reactions to Live-Measles-Virus Vaccine in Children Previously Inoculated with Killed-Virus Vaccine1967 · 79 citations
  4. 4Altered reactivity to measles virus. Atypical measles in children previously immunized with inactivated measles virus vaccines1967 · 358 citations
  5. 5Altered Reactivity to Measles Virus1967 · 270 citations