June 1, 1962British Journal of Pharmacology and ChemotherapyOpen Access

Relation in Rat Hind‐limb Blood Vessels Between Nervous Vasomotor Tone and the Response to Vasoconstrictor Drugs

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Population

Innervated rat hind limb perfused with blood

Comparison

Reduction of nervous vasomotor tone followed by… vs Normal nervous vasomotor tone

Design

Preclinical

Authors

RLR. LavertyRidley College

Discussion

Member takes

Implication

Alerts to potential sympathetic modulation of vasopressor responses in models; leaves open human relevance and clinical translation.

Structured PICO

Population

Innervated rat hind limb perfused with blood

Intervention

Reduction of nervous vasomotor tone (via ganglion blockade, nerve section, or indirect drug effect) followed by administration of vasoconstrictor drugs (noradrenaline, adrenaline, ephedrine, tyramine, 5-hydroxytryptamine, angiotensin, vasopressin, or S-methyl isothiourea)

Comparator

Normal nervous vasomotor tone

Outcome

Vasoconstrictor response of the blood vesselssurrogate

In a rat model, sympathetic nervous system activity directly influences the reactivity of peripheral blood vessels to sympathomimetic drugs.

Cite This Study

R. Laverty (1962) studied this question.

synapsesocial.com/papers/6a94da158ce716a7e9fa53c5 https://doi.org/10.1111/j.1476-5381.1962.tb01167.x

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