May 1, 1984Infection and ImmunityOpen Access

Role of the H-2s haplotype in survival of mice after infection with Trypanosoma cruzi

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Population

Inbred mice infected with 10^3 trypomastigotes of Trypanosoma cruzi Peru

Comparison

Presence of the H-2s haplotype and its… vs Strains without the complete H-2s haplotype or…

Design

Preclinical

Follow-up

17 days for parasitemia, with continued survival monitoring

Authors

RWRuth A. WrightsmanEmory University SKStuart M. KrassnerUniversity of California, Irvine JWJ D WatsonSydney Adventist Hospital

Discussion

Member takes

Implication

Does not inform human Chagas risk stratification or therapy; leaves open MHC and non-MHC genetic contributions to infection outcomes.

Structured PICO

Population

Inbred mice (including strains B10.S, SJL/J, A.SWSn/J, and various congenic/recombinant strains) infected with 10^3 trypomastigotes of Trypanosoma cruzi Peru

Intervention

Presence of the H-2s haplotype and its recombinant variants

Comparator

Strains without the complete H-2s haplotype or with different genetic backgrounds

Outcome

Survival and bloodstream parasitemia levels at day 17hard clinical

Survival of T. cruzi infection in mice requires at least two regions of the H-2s haplotype and is influenced by non-H-2 genetic background genes.

Limitations

Limited by the availability of H-2s recombinant strains, preventing examination of all possible substitutions of H-2 regions

Cite This Study

Wrightsman et al. (1984) studied this question.

synapsesocial.com/papers/6a94db30397e3dbeede610ab https://doi.org/10.1128/iai.44.2.351-354.1984

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