Key result
Neutralizing antibody titers induced by measles vaccination were 2^3.2 times lower than those induced by natural infection and declined significantly by age 20.
Why the study?
Does measles vaccination induce comparable neutralizing antibody titers to natural infection in Japanese individuals across different age groups?
Population
189 residents aged 3 months to 82 years from Osaka Prefecture, Japan. 85 received MV vaccination, 104 did…
Comparison
Measles vaccination (past history) vs Natural measles infection (past history)
Design
Cross-sectional
Authors
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Waning vaccine-induced titers by age 20 may affect adult protection; leaves open optimal dosing in Japanese populations.
Cross-Sectional (n=189)
Does measles vaccination induce comparable neutralizing antibody titers to natural infection in Japanese individuals across different age groups?
Mean Difference: -3.2
Absolute Event Rate: 4.8% vs 8%
p-value: p=<0.0001
Measles vaccine-induced neutralizing antibody titers are significantly lower than those from natural infection and wane by age 20, suggesting a need for a two-dose vaccination program.
Itoh et al. (2002) conducted a cross-sectional in Measles immunity (n=189). Measles vaccination vs. Natural measles infection was evaluated on Neutralizing (NT) antibody titers (log2) in subjects <9 years old (3.2 log2 units lower, p=<0.0001). Neutralizing antibody titers induced by measles vaccination were 2^3.2 times lower than those induced by natural infection and declined significantly by age 20.
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