Key result
Genistein (50 microM) induced a partial inhibition of the pacemaker (I(f)) current (26.6% to 33.6%) by directly interacting with the channel, independent of its tyrosine kinase-inhibitory properties.
Genistein blocks the pacemaker I(f) current by directly interacting with the channel, independent of its tyrosine kinase-inhibitory properties, limiting its utility as a specific pharmacological tool for studying phosphorylation pathways.
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Cautions against genistein as selective tyrosine kinase inhibitor in I(f) studies; leaves open direct channel effects in vivo.
Altomare et al. (2005) studied this question. Genistein was evaluated on Inhibition of the pacemaker (I(f)) current. Genistein (50 microM) induced a partial inhibition of the pacemaker (I(f)) current (26.6% to 33.6%) by directly interacting with the channel, independent of its tyrosine kinase-inhibitory properties.
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