Profile of urinary dapsone/creatinine ratios after oral dosage with dapsone

The ratios of the concentration of DDS plus its diazotisable metabolites to creatinine (D/e ratios) of successive urine samples collected after the ingestion of either single or conse cutive daily doses of 100 mg DDS fo llowed a pattern that was close ly in accord with the hypothesis that once absorption is complete the rate of elimination of DDS and its diazotisable metabolites falls exponentially at a rate similar to the declin e in plasma DDS concentrations. Diuresis in fluen ced D/e ratios to only a minor extent. The results obtained indicated the validity determining dapsone compliance by determining D/e ratios of urine samples from either the individual patient or a group of patients self-administering their prescribed daily DDS medication, provided that the results obtained are compared with those achieved with fully supervised treatment.