Key result
Inward rectifier K+ channels exist on the vascular smooth muscle of the rat middle cerebral artery, producing dilation when activated and aiding in determining resting tone independent of pressure.
Population
Isolated perfused rat middle cerebral artery (MCA)
Comparison
Extraluminal addition of 15 mM K+ and selective… vs Resting conditions or non-selective K+ channel…
Design
Preclinical
Authors
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No immediate clinical implications for cerebral blood flow; leaves open Kir channel relevance to human cerebrovascular tone.
Inward rectifier potassium channels are present on the vascular smooth muscle of rat middle cerebral arteries and contribute to resting vascular tone independently of pressure.
Johnson et al. (1998) studied this question. Potassium (KCl) and Kirs inhibitors (BaCl2, CsCl) was evaluated on Vessel dilation or constriction. Inward rectifier K+ channels exist on the vascular smooth muscle of the rat middle cerebral artery, producing dilation when activated and aiding in determining resting tone independent of pressure.
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