Why the study?
Does amiodarone cause severe neurological complications at usual maintenance doses in patients?
Does amiodarone cause severe neurological complications at usual maintenance doses in patients?
Amiodarone can cause severe, disabling, and potentially irreversible neurological complications even at usual maintenance doses of ≤600 mg/day.
Severe neurological toxicity may occur with amiodarone at standard doses; case reports leave open true incidence and reversibility.
Five patients developed neurological symptoms during treatment with amiodarone for intervals ranging between five and 40 months. In each case the daily maintenance dose did not exceed 600 mg. The neurological manifestations included gait ataxia, tremor, polyneuropathy, and myopathy. In all five patients, the neurological symptoms were severe and disabling. In one patient with a myopathy, there was no improvement after amiodarone was withdrawn. The neurological side effects of amiodarone may be disabling and are not always reversible with drug withdrawal. Neurological complications may arise during treatment with usual maintenance doses.
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Anderson et al. (1985) studied this question.
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