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September 1, 1987Blood

Direct evidence for the interaction of the nucleotide affinity analog 5'-p-fluorosulfonylbenzoyl adenosine with a platelet ADP receptor

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Authors

WFWR FiguresTemple University LSLM Scearce PDP DeFeoThrombosis Research Institute

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Implication

May guide ADP receptor-targeted antiplatelet development; leaves open clinical translation from in vitro data.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Figures et al. (1987) studied this question.

synapsesocial.com/papers/6a94dfb6d002db7cabf57a0a https://doi.org/10.1182/blood.v70.3.796.796

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Two mechanisms for inhibition of ADP-induced platelet shape change by 5'-p-fluorosulfonylbenzoyladenosine. Conversion to adenosine, and covalent modification at an ADP binding site distinct from that which inhibits adenylate cyclase.1985 · 45 citations
2The effects of ATP on platelets: evidence against the central role of released ADP in primary aggregation1975 · 180 citations
3Binding of Adenosine Diphosphate by Isolated Membranes from Human Platelets1974 · 101 citations
4Affinity labeling of a human platelet membrane protein with 5'-p-fluorosulfonylbenzoyl adenosine. Concomitant inhibition of ADP-induced platelet aggregation and fibrinogen receptor exposure.1981 · 56 citations
5AFFINITY LABELING OF PURINE NUCLEOTIDE SITES IN PROTEINS1983 · 218 citations