Experimental study demonstrates chlormerodrin Hg-203 uptake in macrophages and proliferating capillaries after feline cerebral infarction, explaining tracer accumulation on brain scans.
Key Points
To determine the cellular and histological mechanisms responsible for the selective localization of Hg-203-labeled chlormerodrin in infarcted brain tissue.
Conducted a combined histological and radioautographical study in 13 cats with experimentally induced cerebral infarction.
Evaluated the uptake and distribution of Hg-203-labeled chlormerodrin across necrotic, hemorrhagic, and vascularized brain regions.
Radioactive tracer accumulated in infarcted areas within days of lesion onset, with tissue hemorrhage markedly increasing tracer concentration.
Radioautograms demonstrated that Hg-203 selectively localized within macrophages and throughout areas immediately surrounding proliferating capillaries.