The objective of this study was to compare the concentrations of Th1 (IFN-γ , TNF-α) and Th2 (IL-4,IL-10) cytokines in the serum of normal pregnant and recurrent spontaneous abortion (RSA) women in 1st trimester as well as in the normal fertile non pregnant women. In RSA women there was a significant increasing in the mean concentration of Th1 cytokines (TNF- α and IFN- γ) as well as in Th1/TH2 than normal pregnant and non pregnant women. In normal pregnant women there was significant increasing in the mean concentration of Th2 cytokines (IL-4 and IL-10). RSA was associated with increasing concentration of Th1 cytokines while successful pregnancy was associated with increase concentration of Th2 cytokines in the first trimester of pregnancy, indicating Th2 bias in normal pregnancy and a Th1 –bias in unexplained RSA.
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Sharief et al. (2014) studied this question.
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