The Functions of Eosinophils

Editorial Notes1 July 1979The Functions of EosinophilsDAVID A. BASS, M.D., D.PHIL.DAVID A. BASS, M.D., D.PHIL.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-1-120 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEosinophil leukocytes appear to participate in a bewildering array of disease processes that includes allergies, metazoan parasitic infestations, some neoplasms, a few vasculitides, and certain skin diseases. Eosinophilia generally occurs in the setting of repeated or persistent tissue inflammatory responses combined with a hypersensitivity reaction, usually involving immediate (reaginic) or delayed (granulomatous) hypersensitivity but often demonstrating combinations of all possible immune mechanisms. It is not known, however, why one host response (for example, to parasites) elicits eosinophilia while another seemingly similar response (for example, to tuberculin) does not. Further, eosinophilia may be an aberrant reaction, such as to ectopic release...References1. BEESONBASS PD. The Eosinophil. (Major Problems in Internal Medicine Series: Vol. 14.) Philadelphia: W. B. Saunders Company; 1977. Google Scholar2. MAHMOUDWARRENPETERS AKP. A role for the eosinophil in acquired resistance to Schistosoma mansoni infection as determined by antieosinophil serum. J Exp Med. 1975; 142:805-13. CrossrefMedlineGoogle Scholar3. GROVEMAHMOUDWARREN DAK. Eosinophils and resistance to Trichinella spiralis. J Exp Med. 1977; 145:755-9. CrossrefMedlineGoogle Scholar4. BUTTERWORTHDAVIDFRANKS AJD. Antibody-dependent eosinophil-mediated damage to 51Cr-labeled schistosomula of Schistosoma mansoni: damage by purified eosinophils. J Exp Med. 1977; 145:136-50. CrossrefMedlineGoogle Scholar5. KAZURAGROVE JD. 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Blood. 1963; 21:306-21. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine Bowman Gray School of Medicine Wake Forest University Winston-Salem, North Carolina PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCurrent Clinical Practice: Management of the Chronic Leukemias: Special Considerations in the Elderly Patient. Part III. 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Lysozymaktivität im Verlauf der Trichinellose beim KaninchenClinical Observations on the Pathogenesis of Peritoneal Dialysate EosinophiliaBiochemistry and metabolism of human eosinophils 1 July 1979Volume 91, Issue 1Page: 120-121KeywordsAllergic diseasesAllergy and immunologyEosinophiliaEosinophilsHypersensitivityImmune responseSkin diseasesTuberculinVasculitis Issue Published: 1 July 1979 PDF DownloadLoading ...