Key result
Patients with aortic aneurysm had significantly higher back difference elevation values on corneal tomography compared to healthy controls (8.04 μm vs 6.94 μm, p=0.04), suggesting potential early ectatic changes.
Why the study?
Are there corneal tomographic changes indicative of keratoconus in patients with aortic aneurysm compared to healthy controls?
Case-Control (n=68)
No
Are there corneal tomographic changes indicative of keratoconus in patients with aortic aneurysm compared to healthy controls?
Absolute Event Rate: 8.04% vs 6.94%
p-value: p=0.04
Patients with aortic aneurysm exhibit higher back difference elevation on corneal tomography, suggesting a potential shared collagen disorder etiology with corneal ectasia.
Should not yet alter corneal screening in aortic aneurysm; leaves open shared collagenopathy hypothesis for prospective study.
Introduction: To evaluate corneal changes in patients with aortic aneurysm. Methods: The study group (Group 1) included 63 eyes of 33 patients diagnosed with aortic aneurysm and the control group (Group 2) included 69 eyes of 35 healthy people who presented at the Ophthalmology Department. Complete ophthalmologic examination was performed and steepest keratometry measurements were taken via rotational Scheimpflug corneal tomography on the following parameters: sagittal curvature map (S steepest), central corneal thickness (CCT), minimum corneal thickness (CT min), corneal volume (CV), mean pachymetric progression index (PPI mean), minimum PPI (PPI min), maximum PPI (PPI max), maximum Ambrosio relational thickness (ART max), posterior corneal elevation (PE) and back difference elevation (BDE). Results: The groups were similar in terms of age and gender (p=0.082 and p=0.145, respectively). There was no statistically significant difference in visual acuity and intraocular pressure between the groups (p=0.471 and p=0.199 respectively). There was no statistically significant difference in Ks, Kf, Km, CT min, CCT, CV, I-S, S steepest, PE, PPI mean, PPI min, PP max, and ART max values between the groups (p>0.05). BDE value was significantly higher in Group 1 (p=0.04). Discussion and Conclusion: The patients diagnosed with aortic aneurysm should be evaluated for keratoconus.
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Burcu Akıncı (2018) conducted a case-control in Aortic aneurysm (n=68). Aortic aneurysm vs. Healthy volunteers with normal aortic diameters was evaluated on Back difference elevation (BDE) (p=0.04). Patients with aortic aneurysm had significantly higher back difference elevation values on corneal tomography compared to healthy controls (8.04 μm vs 6.94 μm, p=0.04), suggesting potential early ectatic changes.
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