Key result
Homozygosity of the NINJ2 rs11833579 polymorphism was significantly associated with a decreased risk of Alzheimer's disease compared to non-carriers (AOR 0.43).
Why the study?
Do genetic polymorphisms of the NINJ2 gene affect the risk of Alzheimer's disease or vascular dementia in adults aged 50 or older?
Case-Control (n=817)
Yes
Do genetic polymorphisms of the NINJ2 gene affect the risk of Alzheimer's disease or vascular dementia in adults aged 50 or older?
Odds Ratio: 0.43 (95% CI 0.23–0.8)
p-value: p=0.01
Inherited polymorphisms of the vascular susceptibility gene NINJ2 are associated with a decreased risk of Alzheimer's disease, suggesting a shared vascular mechanism in AD pathogenesis.
NINJ2 variant may implicate vascular pathways in AD; hypothesis-generating and should not yet alter clinical risk assessment or screening.
BACKGROUND: Accumulated evidences have shown that vascular risk factors, e.g., hypertension, diabetes mellitus and hyperlipidemia, may be related to the risk of dementia. This study investigated the association between genetic polymorphisms of a vascular susceptibility gene, Ninjurin2 (NINJ2), and the risk of dementia, which has not been explored previously. METHODS: A total of 275 Alzheimer's disease (AD) patients and 119 vascular dementia (VaD) patients aged 50 or older were recruited from three teaching hospitals from 2007 to 2010. Healthy controls (n = 423) with the same age of cases were recruited from the health checkup and volunteers worked at the hospital during the same time period. Five common (frequency >5%) haplotype-tagging single nucleotide polymorphisms (htSNPs) in NINJ2 were genotyped to test for the association between sequence variants of NINJ2 and dementia risk, and how vascular risk factors modify this association. RESULTS: Homozygosity of two NINJ2 SNPs was significantly associated with a decreased risk of AD [rs11833579: adjusted odds ratio (AOR) = 0.43; 95% confidence interval (CI)= 0.23-0.80; rs12425791: AOR= 0.33, 95% CI= 0.12-0.96]. Five common haplotypes (cumulative frequency= 97%) were identified. The global test for the association between NINJ2 haplotypes and AD was significant (p = 0.03). Haplotype CAGGA was significantly associated with a decreased risk of AD (AOR= 0.32, 95% CI= 0.11-0.94). No associations were observed for VaD. CONCLUSION: Inherited polymorphisms of the vascular susceptibility gene NINJ2 were associated with AD risk.
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Lin et al. (2011) conducted a case-control in Alzheimer's disease and Vascular dementia (n=817). NINJ2 genetic polymorphisms (rs11833579 homozygosity) vs. Non-carriers (0 copies) was evaluated on Risk of Alzheimer's disease (AOR 0.43, 95% CI 0.23-0.80, p=0.01). Homozygosity of the NINJ2 rs11833579 polymorphism was significantly associated with a decreased risk of Alzheimer's disease compared to non-carriers (AOR 0.43).
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