The very high prevalence of AD in an Arab population is not explained by APOE ε4 allele frequency

We report data suggesting an autosomal recessive gene for AD. In a recent population-based study we screened all elderly residents of an Arab community (n = 821) located in Wadi Ara, northern Israel. An unusually high prevalence of AD was observed (20% of those ≥65 years, 60.5% of those ≥85 years) compared to other countries even after adjustment for age, education, and gender.1 The APOE e4 allele has been found …