Why the study?
Primary cutaneous angiosarcoma of the head and neck is a rare sarcoma with a poor prognosis and limited treatment options, requiring evaluation of which treatment modalities offer the longest mean overall survival.
Which treatment modalities offer the longest mean overall survival in patients with primary cutaneous angiosarcoma of the head and neck?
Systematic Review (n=1,295)
Which treatment modalities offer the longest mean overall survival in patients with primary cutaneous angiosarcoma of the head and neck?
Absolute Event Rate: 35.9% vs 12.8%
p-value: p=0.001
In patients with primary cutaneous angiosarcoma of the head and neck, combining wide local excision with radiotherapy significantly improves overall survival compared to radiotherapy alone.
Limited data preclude definitive head/neck cAS treatment recommendations; leaves open optimal strategies for prospective trials.
Primary cutaneous angiosarcoma (cAS) of the head and neck is a rare sarcoma with a poor prognosis and limited treatment options. We conducted a systematic review of treatments used for head and neck cAS and determined the treatment modalities that offer the longest mean overall survival (OS). Forty publications totaling 1295 patients were included. Both surgical and nonsurgical modalities have shown potential efficacy in the treatment of cAS; however, limited data preclude definitive recommendations. Multidisciplinary management of cAS should be considered to tailor treatment on a case-by-case basis.
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Jessica Houpe (2023) conducted a systematic review in Primary cutaneous angiosarcoma of the head and neck (n=1,295). Wide local excision (WLE) with radiotherapy (RT) vs. Radiotherapy (RT) alone was evaluated on Mean overall survival (OS) in months (p=0.001).
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