Impact of surgical bladder catheter implantation on voiding function in mice

This study provides the first characterization of voiding behavior and bladder function changes following surgical bladder catheter implantation in mice, as measured using noninvasive assays. We show that surgical catheter implantation reduces bladder capacity and significantly alters voiding parameters, including frequency, volume, and intermicturition intervals, with overall consistent effects across sexes. These findings highlight the importance of accounting for procedural artifacts when interpreting LUT function in preclinical models, ensuring translational relevance for future studies.