Answers are grounded in this paper and cite their sources.
The Mitsunobu reaction occurs typically with inversion of configuration in secondary alcohol derivatives. In this paper, a mechanistic explanation for lactonizations of hindered alcohols under Mitsunobu conditions with retention is proposed. This involves the intermediacy of an acyloxyphosphonium salt followed by acyl transfer to the alcohol.
No takes yet. Share an insight, caveat, or question.
Ahn et al. (2002) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: