The molecular effects of substances present in tobacco and cancer development have been well described. Morphological studieshave demonstrated tissue changes in patients with these lesions and tobacco substances. However, the effects of the tobaccocomponents and the development of potentially malignant lesions remain unknown.Materials and MethodsThus, by chemical-biological analysis, we investigated compounds present in tobacco and the expression of genes involved in theetiopathogenesis of actinic cheilitis.Results and DiscussionAnalysis showed a ratio of 51 harmful substances present in tobacco that are involved in several biological processes that cancause abnormal epithelial-mesenchymal transition pathway. Also, describe how cadmium can adversely affect signaling and celldifferentiation through the inhibition of specific proteins.ConclusionThis study provides the first approach that describes how different tobacco constituents affect a vast network of biological processesin the development of actinic cheilitis and possible progression of the lip carcinoma.
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Leal et al. (2018) studied this question.
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