Key result
Multi-view RVLS analysis from the apical window showed significantly reduced RVLS in children with rTOF compared to controls, and correlated strongly with CMR-RVEF (r=-0.667 to -0.808, P<0.001).
Why the study?
Quantitative echocardiographic evaluation of RV function remains challenging, and no study had assessed RV systolic function in repaired tetralogy of Fallot using a standardized four-view iRotate model from a single apical view.
Does multi-view analysis of RVLS from an apical window using speckle tracking echocardiography accurately evaluate right ventricular systolic function compared to CMR in children with repaired tetralogy of Fallot?
Case-Control
Does multi-view analysis of RVLS from an apical window using speckle tracking echocardiography accurately evaluate right ventricular systolic function compared to CMR in children with repaired tetralogy of Fallot?
Answers are grounded in this paper and cite their sources.
Multi-view speckle tracking echocardiography from a single apical window provides an accurate assessment of right ventricular systolic function in children with repaired tetralogy of Fallot, correlating strongly with cardiac magnetic resonance.
BACKGROUND: Challenges remain in quantitative evaluation of right ventricular (RV) function by echocardiography. Multiple-view assessment is believed to provide a more comprehensive quantification of RV function than conventional single-view analysis. Peak systolic longitudinal RV strain (RVLS) measured by speckle tracking echocardiography (STE) has clinical and prognostic value. No study has investigated RV systolic function in the repaired tetralogy of Fallot (rTOF) using a standardized four-view iRotate model from one apical view. Herein, we examined the feasibility and accuracy of the four-view analysis from apical window in quantitation of RVLS among children with rTOF. METHODS: ) and fractional area change(FAC) were obtained. RVLS of four free-walls were analyzed by dedicated RV speckle tracking software. Echocardiographic parameters were compared with the right ventricular ejection fraction (RVEF) measured by the cardiac magnetic resonance (CMR) in children with rTOF. RESULTS: Multi-view RVLS analysis from apical window was feasible in 35 children with rTOF and all the controls. Compared with age- and gender-matched controls, RVLS of the anterior, lateral, inferior-a, and inferior-b walls were significantly reduced in children with rTOF (P < 0.001). RVLS of the anterior, lateral, inferior-a, and inferior-b walls correlated well with CMR-RVEF in children with rTOF (r = -0.667, -0.743, -0.808, -0.695, P < 0.001). CONCLUSIONS: Multi-view analysis of RVLS from apical window can be applied to evaluate the RV function in children with rTOF. RVLS of the inferior wall-a in the aortic view is a novel and accurate indicator of RV function because of its good reproducibility and strong correlation with CMR-RVEF.
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Bao et al. (2018) conducted a case-control in Repaired tetralogy of Fallot (rTOF). Multi-view RVLS analysis from apical window vs. Age- and gender-matched controls was evaluated on Peak systolic longitudinal RV strain (RVLS) and correlation with CMR-RVEF (r = -0.667 to -0.808, p=<0.001). Multi-view RVLS analysis from the apical window showed significantly reduced RVLS in children with rTOF compared to controls, and correlated strongly with CMR-RVEF (r=-0.667 to -0.808, P<0.001).
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