Key result
High blood glucose levels are associated with the development and progression of microvascular and macrovascular complications in patients with diabetes.
Why the study?
Does blood glucose control reduce the risk of microvascular and macrovascular complications in patients with diabetes?
Does blood glucose control reduce the risk of microvascular and macrovascular complications in patients with diabetes?
Glycemic control is strongly associated with reduced microvascular complications in diabetes, and observational evidence suggests a link to reduced cardiovascular risk, highlighting the need for randomized trials.
Answers are grounded in this paper and cite their sources.
Supports glycemic targets to limit complications; leaves open macrovascular risk reduction, requiring randomized trials.
High blood glucose levels for several years is the major factor in the development and progression of microvascular complications in IDDM. Reducing mean blood glucose reduces the risk of progression of diabetic microvascular complications substantially. A curve-linear relationship exists between HbA1c levels and progression of diabetic retinopathy. Recent evidence also points to a close relationship between high blood glucose levels and progression of microvascular complications in NIDDM. The relationship between mean blood glucose and cardiovascular disease in diabetes has been unclear. Recent population-based studies give evidence for a linear association of glycemic control with the risk for cardiovascular disease in patients with NIDDM. However, randomized studies comparing different degrees of glycemic control in NIDDM and their impact on cardiovascular morbidity and mortality are urgently needed.
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Kristian F. Hanssen (1997) conducted a review in Diabetes (IDDM and NIDDM). Blood glucose control was evaluated on Microvascular and macrovascular complications. High blood glucose levels are associated with the development and progression of microvascular and macrovascular complications in patients with diabetes.
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