Synthesis and characterization of novel poly(γ‐benzyl‐ L ‐glutamate) derivatives tailored for the preparation of nanoparticles of pharmaceutical interest

Four poly(γ‐benzyl‐ L ‐glutamate) (PBLG) derivatives bearing at one end specific groups were synthesized by ring‐opening polymerization of the corresponding γ‐benzyl‐ L ‐glutamate N ‐carboxyanhydride using different amine‐terminated initiators. These moieties were chosen to introduce, on demand, specific functionalities in nanoparticles of pharmaceutical interest. The PBLG and PBLG derivatives were characterized by 1 H NMR, viscosimetry, Fourier transform infrared spectroscopy and differential scanning calorimetry. Nanoparticles smaller than 100 nm in diameter could be easily prepared from these PBLG derivatives by slight modification of a known nanoprecipitation technique.