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The first two-photon upconversion photocatalysis for challenging C–N bond formations was reported. A robust, recyclable NaYF 4,Yb:Er/Co 3 O 4 /g-C 3 N 4 nanosheet platform operated under mild, aerobic conditions with near-infrared light via an ETU-FRET relay. Its utility was demonstrated in synthesizing anticancer JNK3 inhibitor precursors and the late-stage functionalization of ibuprofen, establishing a versatile new paradigm for accessing and modifying medicinally important molecules.
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Zeng et al. (2025) studied this question.
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