Key result
Treatment with steroids, cyclophosphamide, and mycophenolate mofetil led to excellent recovery and disease remission in an elderly female with DADA2 presenting with intestinal ulcers and stroke.
Why the study?
Deficiency of adenosine deaminase 2 is a recently identified monogenic systemic inflammatory vasculopathy with variable phenotypes, and the majority of reported patients are pediatric.
Case Report (n=1)
DADA2, typically a pediatric disease, can present in elderly patients with intestinal ulcers and hemorrhagic stroke and responds to immunosuppressive therapy.
DADA2 evaluation may be warranted in elderly patients with ulcers and stroke; extends phenotype but leaves generalizability open.
Deficiency of adenosine deaminase 2 (DADA2) is a recently identified monogenic systemic inflammatory vasculopathy with variable clinical phenotype. The majority of reported patients are in pediatric age group. In this case report, we present a case of DADA2 in an elderly female, who presented initially with multiple episodes of loose motions with bleeding per rectum and was diagnosed endoscopically as multiple rectal hemorrhagic ulcers. During her hospital stay, she had generalized tonic-clonic seizures and was detected to have a hemorrhagic stroke. The patient was managed with steroids, cyclophosphamide, and other supportive measures. She had excellent recovery with the disease in remission on low-dose steroids and mycophenolate mofetil.
No takes yet. Share an insight, caveat, or question.
Jha et al. (2021) conducted a case report in Deficiency of adenosine deaminase 2 (DADA2) (n=1). Steroids, cyclophosphamide, and mycophenolate mofetil was evaluated on Clinical recovery. Treatment with steroids, cyclophosphamide, and mycophenolate mofetil led to excellent recovery and disease remission in an elderly female with DADA2 presenting with intestinal ulcers and stroke.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: